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🧪 Chemistry  ·  Biomolecules  ·  NEET & JEE

In the beta-pleated sheet, adjacent polypeptide chains are held by:

Answer: Intermolecular hydrogen bonds between backbone groups.

  • A Intermolecular hydrogen bonds between backbone groups
  • B Disulfide bonds formed between adjacent cysteine residues
  • C Ionic bonds between oppositely charged side chains
  • D Hydrophobic interactions between nonpolar side chains

Correct answer: A. Intermolecular hydrogen bonds between backbone groups

Explanation: Beta-sheets are stabilised by hydrogen bonds between NH and C=O groups on adjacent parallel or antiparallel chains.

Peptide Bond Formation (Condensation)H₂N-CH(R₁)-C(=O)OHAmino acid 1+HNH-CH(R₂)-COOHAmino acid 2H₂N-CH(R₁)-CO-NH-CH(R₂)-COOHDipeptide+ H₂OThe -OH (from acid 1) and -H (from amine 2) combine to release water, forming the -CO-NH- peptide bond

Two amino acids join via a condensation reaction: the carboxyl -OH of one and an amine -H of the other are eliminated as water, leaving a peptide bond (-CO-NH-) linking them into a dipeptide; repeating this builds a full protein chain.

Concept context

The chemistry of life: carbohydrates, proteins, lipids, nucleic acids, enzymes, and vitamins. Understand their structures, classification, and biological functions. Highly relevant for NEET and Class 12 board exams.

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