Zaymiey

🔬 Biology  ·  Cell Cycle and Cell Division  ·  NEET

The SAC (spindle assembly checkpoint) is satisfied when:

Answer: Every kinetochore has tension from being attached to microtubules from opposite poles.

  • A Every chromosome has largely condensed in preparation for upcoming division in typical laboratory settings
  • B Every kinetochore has tension from being attached to microtubules from opposite poles
  • C Cytokinesis has already begun and the cleavage furrow is actively forming under usual circumstances
  • D DNA replication has largely completed across the entire genome sequence according to most researchers

Correct answer: B. Every kinetochore has tension from being attached to microtubules from opposite poles

Explanation: SAC is silenced only when ALL kinetochores have amphitelic (bioriented) attachments generating tension. Mad2 is released from kinetochores, allowing APC/C activation.

The Cell CycleG1SG2M (Mitosis)G1+S+G2 = Interphase (the longest part of the cycle, where the cell spends most of its time)

The cell cycle: G1 (growth and preparation), S (DNA replication, chromosome number stays 2n but DNA content doubles), G2 (final checks before division), and M (mitosis itself) - together, G1+S+G2 make up interphase.

Concept context

Mitosis and meiosis: how cells divide for growth, repair, and reproduction.

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