Answer: Multiple mitotic steps: centrosome maturation, APC/C activation, kinetochore function, cytokinesis.
- A Initiating the very first round of DNA replication at origins by recruiting licensing factors to the unfired pre-RC complexes
- B Multiple mitotic steps: centrosome maturation, APC/C activation, kinetochore function, cytokinesis
- C Driving chromosome pairing and synapsis specifically during meiosis I via direct loading of SYCP proteins onto paired homologs
- D Maintaining the G<sub>1</sub> interphase checkpoint arrest exclusively through sustained inhibition of cyclin-dependent kinase activity
Correct answer: B. Multiple mitotic steps: centrosome maturation, APC/C activation, kinetochore function, cytokinesis
Explanation: PLK1 has multiple roles: centrosome separation, spindle assembly, chromosome segregation via kinetochore function, and cytokinesis initiation.
The cell cycle: G1 (growth and preparation), S (DNA replication, chromosome number stays 2n but DNA content doubles), G2 (final checks before division), and M (mitosis itself) - together, G1+S+G2 make up interphase.
Concept context
Mitosis and meiosis: how cells divide for growth, repair, and reproduction.