Answer: Cells exit mitosis without completing cell division (due to slow APC/C activation) and become aneuploid.
- A Chromosomes that largely fail to condense properly before mitosis begins under most conditions encountered
- B Cells exit mitosis without completing cell division (due to slow APC/C activation) and become aneuploid
- C The spindle assembly checkpoint becomes unusually and abnormally stringent over time as frequently observed in practice
- D Cytokinesis alone fails while chromosome segregation otherwise proceeds normally in many documented cases
Correct answer: B. Cells exit mitosis without completing cell division (due to slow APC/C activation) and become aneuploid
Explanation: Mitotic slippage: slow degradation of cyclin B (despite SAC) eventually drops CDK1 activity below the threshold. Cell exits mitosis prematurely without division, generating aneuploid daughter or tetraploid cell.
The cell cycle: G1 (growth and preparation), S (DNA replication, chromosome number stays 2n but DNA content doubles), G2 (final checks before division), and M (mitosis itself) - together, G1+S+G2 make up interphase.
Concept context
Mitosis and meiosis: how cells divide for growth, repair, and reproduction.