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What is the role of ubiquitin in protein quality control?

Answer: It tags damaged proteins for proteasomal degradation.

  • A It directly refolds misfolded polypeptides back into their native conformation
  • B It tags damaged proteins for proteasomal degradation
  • C It functions as a molecular chaperone that shields nascent chains from aggregation
  • D It binds ribosomes to halt ongoing translation of damaged mRNA transcripts

Correct answer: B. It tags damaged proteins for proteasomal degradation

Explanation: Ubiquitin is a small protein that marks damaged or misfolded proteins for degradation by the 26S proteasome. Poly-ubiquitination signals rapid destruction.

Enzyme Kinetics: Rate vs Substrate Concentration[Substrate]Reaction rateVmaxKm½VmaxCurve flattens at high [S]: ALL enzyme active sites are occupied (saturation)

As substrate concentration rises, reaction rate increases steeply at first, then plateaus at Vmax once every enzyme molecule is working at full capacity; Km is the substrate concentration giving half-maximal rate, and a LOWER Km means the enzyme reaches that rate with less substrate (higher affinity).

Concept context

Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.

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