Answer: Fischer.
- A Koshland
- B Fischer
- C Michaelis
- D Pauling
Correct answer: B. Fischer
Explanation: Emil Fischer proposed the lock-and-key model in 1894, suggesting the enzyme active site is rigid and complementary to the substrate. Koshland later proposed the induced fit model in 1958.
As substrate concentration rises, reaction rate increases steeply at first, then plateaus at Vmax once every enzyme molecule is working at full capacity; Km is the substrate concentration giving half-maximal rate, and a LOWER Km means the enzyme reaches that rate with less substrate (higher affinity).
Concept context
Carbohydrates, proteins, lipids, nucleic acids, and enzyme kinetics. Essential foundation for understanding metabolism.