Answer: Acetamide group is less activating and less susceptible to oxidation.
- A Acetamide group is less activating and less susceptible to oxidation
- B It increases the aqueous solubility of the aromatic ring according to most researchers
- C It increases the basicity of the nitrogen lone pair in the majority of cases studied
- D It allows the amine to form salts readily with mineral acids as widely reported
Correct answer: A. Acetamide group is less activating and less susceptible to oxidation
Explanation: N-acetylation converts the strongly activating -NH<sub>2</sub> to -NHCOCH<sub>3</sub>, making the ring less reactive and protecting the group.
In aniline, the nitrogen's lone pair is pulled into the benzene ring through resonance, leaving less electron density available to accept a proton - which is why aniline is a much weaker base than methylamine, where the lone pair is fully available.
Concept context
Nitrogen-containing organic compounds. Covers classification (primary, secondary, tertiary), basicity comparison, preparation methods, and reactions including diazotization and coupling, key for understanding dyes and pharmaceuticals.