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🧪 Chemistry  ·  Aldehydes, Ketones and Carboxylic Acids  ·  NEET & JEE

Which carbonyl compound is least reactive towards nucleophilic addition?

Answer: Acetone.

  • A Formaldehyde
  • B Acetaldehyde
  • C Acetone
  • D Benzaldehyde

Correct answer: C. Acetone

Explanation: Acetone is least reactive due to steric hindrance and +I effect of two methyl groups reducing electrophilicity.

Nucleophilic Addition to C=ONu:-CORR'CO-RR'Nu

Curved arrows show the nucleophile attacking the carbonyl carbon while the C=O pi electrons move onto oxygen, giving a tetrahedral alkoxide intermediate.

Concept context

Aldehydes, ketones, carboxylic acids, and their derivatives (esters, amides, acid chlorides). Key reactions include nucleophilic addition, Aldol condensation, Cannizzaro, and Claisen. Very heavily tested in JEE and NEET.

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