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🔬 Biology  ·  Digestion and Absorption  ·  NEET

Vitamin B12 absorption in the ileum specifically requires:

Answer: Binding to intrinsic factor secreted by gastric parietal cells.

  • A Direct transport coupled to sodium-glucose cotransporters
  • B Conjugation with bile salts in the duodenum
  • C Binding to intrinsic factor secreted by gastric parietal cells
  • D Hydrolysis by pancreatic amylase before uptake

Correct answer: C. Binding to intrinsic factor secreted by gastric parietal cells

Explanation: Vitamin B12 must bind intrinsic factor, secreted by gastric parietal cells, to form a complex that is recognized and absorbed by specific receptors in the ileum.

Labeled diagram of the human digestive system showing mouth, esophagus, stomach, liver, pancreas, small intestine, and large intestine

The human digestive system. Image: LadyofHats (Mariana Ruiz), Public Domain, via Wikimedia Commons.

Concept context

The digestive tract, digestive enzymes, hormonal control of digestion, and liver function. High NEET weightage.

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